Investigation of Estrogen Receptor (ESR1) for Breast Cancer from Traditional Chinese Medicine

ASIA unversity > 資訊學院 > 生物資訊與醫學工程學系 > 期刊論文 > Item 310904400/81270

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/81270

题名:	Investigation of Estrogen Receptor (ESR1) for Breast Cancer from Traditional Chinese Medicine
作者:	Tzu-Chieh Hung;Wen-Yuan Lee;Kuen-Bao Chen;Yueh-Chiu Chan;Calvin Yu-Chian Chen
贡献者:	生物與醫學資訊學系
日期:	2014-06
上传时间:	2014-10-08 05:56:18 (UTC+0)
摘要:	Recently, an important topic of breast cancer had been published in 2013. In this report, estrogen receptor (ESR1) had defined the relation of hormone-cause breast cancer. The screening of traditional Chinese medicine (TCM) database has found the molecular compounds by simulating molecular docking and molecular dynamics to regulate ESR1. S-Allylmercaptocysteine and 5-hydroxy-L-tryptophan are selected according to the highest docking score than that of other TCM compounds and Raloxifene (control). The simulation from molecular dynamics is helpful in analyzing and detecting the protein-ligand interactions. After a comparing the control and the Apo form, then based on the docking poses, hydrophobic interactions, hydrogen bond and structure variations, this research postulates that S-allylmercaptocysteine may be more appropriate than other compounds for protein-ligand interaction.
關聯:	JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
显示于类别:	[生物資訊與醫學工程學系 ] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
index.html	0Kb	HTML	334	检视/开启

在ASIAIR中所有的数据项都受到原著作权保护.