Vasorelaxing and antihypertensive activities of synthesized peptides derived from computer-aided simulation of pepsin hydrolysis of yam dioscorin

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/81163

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题名:	Vasorelaxing and antihypertensive activities of synthesized peptides derived from computer-aided simulation of pepsin hydrolysis of yam dioscorin
作者:	林音秀;Lin, Yin-Shiou;呂岳霖;Lu, Yeh-Lin;汪貴珍;Wang, Guei-Jane;Lia, Hong-Jen;Liang, Hong-Jen;Hou, Wen-Chi;Hou, Wen-Chi
贡献者:	保健營養生技學系
关键词:	Angiotensin converting enzyme;Antihypertensive activity;Blood pressure;Vasorelaxing;Yam dioscorin
日期:	2014-06
上传时间:	2014-10-01 08:48:13 (UTC+0)
摘要:	Background We reported that yam dioscorin and its peptic hydrolysates exhibited ACE inhibition and antihypertensive effects on SHRs, however, the active peptides are not really isolated until now. Using ACE inhibitory screenings, two penta-peptides, KTCGY and KRIHF, were selected for ex vivo and in vivo experiments. Results KTCGY, KRIHF, and captopril were shown to have similar vasodilating effects against phenylephrine (PE)-induced tensions in rat endothelium-dependent thoracic aortic rings, however, KTCGYKTCGY (two-repeated KTCGY) and TCGYTCGY (two-repeated TCGY) were showed endothelium-independent vasodilating effects against PE-induced tensions. KTCGY, KRIHF (10 or 20 mg/kg), and captopril (10 mg/kg) were used to evaluate antihypertensive activity during 24-h after a single oral administration to spontaneously hypertensive rats (SHRs). The KTCGY and KRIHF showed significantly different and reduced the systolic blood pressure of SHRs compared to the blank. Conclusions These results suggest that KTCGY and KRIHF may contribute important roles in yam dioscorin for regulating blood pressure in vivo.
關聯:	Botanical Studies,55:49
显示于类别:	[食品營養與保健生技學系] 期刊論文

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