The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/81155

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题名:	The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats
作者:	Li-Min Liu;Shu-Fen Cheng;Po-Chuen Shieh;Jang-Chang Lee;Jih-Jung Chen;Chi-Tang Ho;Sheng-Chu Kuo;Daih-Huang Kuo;Li-Jiau Huang;Tzong-Der Way
贡献者:	保健營養生技學系
关键词:	Euonymus laxiflorus;Gardenia jasminoides;Gout;Rubia lanceolata;Xanthine oxidase
日期:	2014-05
上传时间:	2014-10-01 08:47:20 (UTC+0)
摘要:	Chinese herbal medicinal plants, Euonymus laxiflorus (EL), Rubia lanceolata (RL) and Gardenia jasminoides (GJ), have been used wildly to treat arthritis and gout in Taiwan for decades. To understand the beneficial effects of these three plants, their xanthine oxidase (XO) inhibitory activity in vitro and hypouricaemic activity in vivo were investigated. Our results suggested that methanol extracts were better than water extracts for inhibition of XO activity and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, except the water extract of GJ, which exhibited the strongest radical scavenging effect. In animal study, the serum urate level was significantly decreased after oral administration of higher dose (0.39g/kg) methanol extract of the mixture of three plants (ERG). In addition, methanol extract of ERG reduced the pain reaction time in the second phase of formalin induced pain. The results provide useful information on the pharmacological activities of these plants for the potential in treating hyperuricemia.
關聯:	FOOD AND CHEMICAL TOXICOLOGY,70:179-184.
显示于类别:	[食品營養與保健生技學系] 期刊論文

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