A new approach for noninvasive transdermal determination of blood uric acid levels

ASIA unversity > 資訊學院 > 光電與通訊學系 > 期刊論文 > Item 310904400/81152

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/81152

Title:	A new approach for noninvasive transdermal determination of blood uric acid levels
Authors:	程德勝 Yong, KK;Yong, KK;Yao, YD;Yao, YD;Shen, HT;Shen, HT;Hsieh, SM;Hsieh, SM;Jheng, DY;Jheng, DY;Sun, TP;Sun, TP;Shieh, HL;Shieh, HL
Contributors:	光電與通訊學系
Keywords:	biosensor;electroporation;laser;noninvasive;reverse iontophoresis;uric acid
Date:	2014-06
Issue Date:	2014-10-01 08:46:59 (UTC+0)
Abstract:	The aims of this study were to investigate the most effective combination of physical forces from laser, electroporation, and reverse iontophoresis for noninvasive transdermal extraction of uric acid, and to develop a highly sensitive uric acid biosensor (UAB) for quantifying the uric acid extracted. It is believed that the combination of these physical forces has additional benefits for extraction of molecules other than uric acid from human skin. A diffusion cell with porcine skin was used to investigate the most effective combination of these physical forces. UABs coated with ZnO₂ nanoparticles and constructed in an array configuration were developed in this study. The results showed that a combination of laser (0.7 W), electroporation (100 V/cm(2)), and reverse iontophoresis (0.5 mA/cm(2)) was the most effective and significantly enhanced transdermal extraction of uric acid. A custom-designed UAB coated with ZnO₂ nanoparticles and constructed in a 1×3 array configuration (UAB-1×3-ZnO₂) demonstrated enough sensitivity (9.4 μA/mM) for quantifying uric acid extracted by the combined physical forces of laser, electroporation, and RI. A good linear relationship (R(2)=0.894) was demonstrated to exist between the concentration of uric acid (0.2-0.8 mM) inside the diffusion cell and the current response of the UAB-1×3-ZnO₂. In conclusion, a new approach to noninvasive transdermal extraction and quantification of uric acid has been established.
Relation:	International Journal of Nanomedicine;9:3069-76.
Appears in Collections:	[光電與通訊學系] 期刊論文

Files in This Item:

File	Size	Format
index.html	0Kb	HTML	547	View/Open

Loading...