ASIA unversity:Item 310904400/81151
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    题名: Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats
    作者: Hsien-Tsung;Yao, Hsien-Tsung;Hsu, Ya-Ru;Hsu, Ya-Ru;李宗貴;Lii, Chong-Kuei;Lin, Ai-Hsuan;Lin, Ai-Hsuan;Cha, Keng-Hao;Chang, Keng-Hao;Yan, Hui-Ting;Yang, Hui-Ting
    贡献者: 保健營養生技學系
    关键词: Black tea;Drug-metabolizing enzymes;Green tea;Oxidative stress;Rats
    日期: 2014-06
    上传时间: 2014-10-01 08:46:55 (UTC+0)
    摘要: The effect of commercially available green tea (GT) and black tea (BT) drinks on drugmetabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory chow diet and GT or BT drink for 5weeks. Control rats received de-ionized water instead of the tea drinks. Rats received the GT and BT drinks treatment for 5weeks showed a significant increase in hepatic microsomal cytochrome P450 (CYP) 1A1 and CYP1A2, and a significant decrease in CYP2C, CYP2E1 and CYP3A enzyme activities. Results of immunoblot analyses of enzyme protein contents showed the same trend with enzyme activity. Significant increase in UDP-glucuronosyltransferase activity and reduced glutathione content in liver and lungs were observed in rats treated with both tea drinks. A lower lipid peroxide level in lungs was observed in rats treated with GT drink. Electrophoretic mobility shift assay revealed that both tea drinks decreased pregnane X receptor binding to DNA and increased nuclear factor-erythroid 2 p45-related factor 2 binding to DNA. These results suggest that feeding of both tea drinks to rats modulated DME activities and reduced oxidative stress in liver and lungs. GT drink is more effective on reducing oxidative stress than BT drink.
    Copyright © 2014 Elsevier Ltd. All rights reserved.
    關聯: FOOD AND CHEMICAL TOXICOLOGY;70:120-7.
    显示于类别:[食品營養與保健生技學系] 期刊論文

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