Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1

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题名:	Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1
作者:	Rezai-Zadeh N;Zhang X;Namour F;Fejer G;Wen YD;Yao YL;Gyory I;Wright K;Seto E
贡献者:	Department of Biotechnology
关键词:	Histone methyltransferase;PRMT1;transcription factor YY1
日期:	2003
上传时间:	2010-03-15 08:11:15 (UTC+0)
出版者:	Asia University
摘要:	Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone methyltransferases (HMTs) and elucidating the consequences of histone methylation, little is known about the recruitment of HMTs to regulatory regions of chromatin. Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter. Our data confirm that histone methylation does not occur randomly but rather is a targeted event and provides one mechanism by which HMTs can be recruited to chromatin to activate gene expression.
關聯:	Genes & Development 17(8):10-19
显示于类别:	[生物科技學系] 期刊論文

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