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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79910


    Title: Citrus medica var. sarcodactylis;Foshou) Activates Fibroblast Growth Factor-2 Signaling to Induce Migration of RSC96 Schwann Cells
    Authors: 黃志揚;HUANG, CHIH-YANG;Kuo, Wei-Wen;Kuo, Wei-Wen;Marthandam, A;Marthandam Asokan Shibu,;Hs, Ming-Fang;Hsueh, Ming-Fang;Yueh-Sheng, C;Chen, Yueh-Sheng;蔡輔仁;Tsai, Fuu-Jen;Yao, Chun-Hsu;Yao, Chun-Hsu;Chien-Chung;Lin, Chien-Chung;Pan*, Lung-Fa;Pan*, Lung-Fa;Ju, Da-Tong;Ju, Da-Tong
    Contributors: 生物科技學系
    Date: 2014
    Issue Date: 2014-07-03 07:42:01 (UTC+0)
    Abstract: Factors that enhance the intrinsic growth potential of neurons play a major role in the regeneration and repair of adult neurons following an injury. Fibroblast growth factor (FGF-2) is one of the key players in the origin and growth of neuronal and glial cells through autocrine and paracrine signaling. Water extract of Citrus medica var. sarcodactylis (fingered citron, foshou), which is been used effectively as a Chinese herbal medicine, was found to activate the FGF-2 promoter in transgenic luciferase expression models. Foshou treatment on Schwann cells (RSC96) transfected with luciferase reporter plasmid under a FGF-2 promoter was found to induce the FGF-2 promoter and showed enhanced luciferase expression. The FGF-2 expression was accompanied with an increase in the expression of proteins involved in cell migration and cell proliferation in a dose dependent manner. Therefore, foshou potentially enhances nerve regeneration by inducing the Schwann cell proliferation and migration.
    Relation: AMERICAN JOURNAL OF CHINESE MEDICINE;42(2):443-52.
    Appears in Collections:[Department of Biotechnology] Journal Article

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