Resistance to Irinotecan ;CPT-11) activates Epidermal Growth Factor Receptor/Nuclear Factor Kappa B and Increases Cellular Metastasis and Autophagy in LoVo Colon Cancer Cells

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Title:	Resistance to Irinotecan;CPT-11) activates Epidermal Growth Factor Receptor/Nuclear Factor Kappa B and Increases Cellular Metastasis and Autophagy in LoVo Colon Cancer Cells
Authors:	Ming-Cheng, C;Chen, Ming-Cheng;Le, Nien-Hung;Lee, Nien-Hung;Tsung-Jung, H;Ho, Tsung-Jung;Hs, Hsi-Hsien;Hsu, Hsi-Hsien;郭家驊;郭薇雯;Lin, Yueh-Min;Lin, Yueh-Min;蔡輔仁;Tsai, Fuu-Jen;蔡長海;黃志揚;HUANG, CHIH-YANG
Contributors:	健康產業管理學系
Keywords:	Autophagy;CPT-11;Chemoresistance;Metastasis;NF-κB
Date:	2014
Issue Date:	2014-06-05 04:02:38 (UTC+0)
Abstract:	Chemotherapy is usually applied to treat colon cancer but leads to chemoresistance, and increased metastasis and invasion. The main focus of this study is to observe effects of resistance to irinotecan (CPT-11) on metastasis, invasion and autophagy in CPT-11 resistant (CPT-11-R) LoVo colon cancer cells. CPT-11, a topoisomerase I inhibitor and a first-line chemotherapeutic drug, is used to treat colon cancer. CPT-11-R cells were constructed in a step-wise fashion with increasing CPT-11 doses. The CPT-11-R strain had a significantly lower expression of Wnt/β-catenin pathway, but induced an EGFR/IKKα/β/NF-κB pathway with elevated cell cycle, metastasis and basal autophagy. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Relation:	CANCER LETTERS;349(1):51-60.
Appears in Collections:	[Department of International Business] Journal Artical

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