APPLICATION OF LC-MS/MS IN IDENTIFICATION OF TOXIN IN THE CAUSATIVE GASTROPOD AND VICTIM SAMPLES

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/79735

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题名:	APPLICATION OF LC-MS/MS IN IDENTIFICATION OF TOXIN IN THE CAUSATIVE GASTROPOD AND VICTIM SAMPLES
作者:	Chun-Lan Lin;Cheng-Hong Hsieh;You-Liang Hsieh;Yi-Cheng Tai;Deng-Fwu Hwang
贡献者:	保健營養生技學系
关键词:	food poisoning;gastropod;TTX;Nassariidae;LC-MS/MS
日期:	201405
上传时间:	2014-06-05 04:00:47 (UTC+0)
摘要:	Food paralytic poisoning incident was detected in the gastropod Nassariidae Niotha clathrata and Zeuxis scalaris occurred in December 2012 in Kaohsiung, Taiwan. The toxin was purified from each remain of cooked gastropod and victim tissues by ultrafiltration using a YM-3 membrane, followed by C18 cartridge column purification. Based on analyses by LC-MS/MS, the causative agent of gastropod food poisoning was identified as tetrodotoxin. The toxicity of remain of cooked sample was 245 MU/g (1MU = 0.178 μg TTX) for N. clathrata and 203 MU/g for Z. scalaris. The blood and excrements of victim was shown to contain TTX of 0.13 and 0.18 μg/g, respectively. There was positive between results from LC-MS/MS and mouse bioassay in the causative gastropod. The LC-MS/MS method is suitable for rapid screening of TTX.
關聯:	Journal of Marine Science and Technology-Taiwan, 21(Suppl),52-57.
显示于类别:	[食品營養與保健生技學系] 期刊論文

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