ASIA unversity:Item 310904400/79717
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    题名: Anti-Neuroinflammatory Effects of the Calcium Channel Blocker Nicardipine on Microglial Cells: Implications for Neuroprotection
    作者: Bor-Ren Huang;Pei-Chun Chang;Wei-Lan Yeh;Chih-Hao Lee;Cheng-Fang Tsai;Chingju Lin;Hsiao-Yun Lin;Yu-Shu Liu;Caren Yu-Ju Wu;Pei-Ying Ko;Shiang-Suo Huang;Horng-Chaung Hsu;Dah-Yuu Lu
    贡献者: 生物科技學系
    日期: 2014-03
    上传时间: 2014-06-05 03:58:00 (UTC+0)
    摘要: Background/Objective

    Nicardipine is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. However, accumulating evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play important roles in neurodegeneration, and the effect of nicardipine on microglial activation remains unresolved.

    Methodology/Principal Findings

    In the present study, using murine BV-2 microglia, we demonstrated that nicardipine significantly inhibits microglia-related neuroinflammatory responses. Treatment with nicardipine inhibited microglial cell migration. Nicardipine also significantly inhibited LPS plus IFN-γ-induced release of nitric oxide (NO), and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, nicardipine also inhibited microglial activation by peptidoglycan, the major component of the Gram-positive bacterium cell wall. Notably, nicardipine also showed significant anti-neuroinflammatory effects on microglial activation in mice in vivo.

    Conclusion/Significance

    The present study is the first to report a novel inhibitory role of nicardipine on neuroinflammation and provides a new candidate agent for the development of therapies for inflammation-related neurodegenerative diseases.
    關聯: PLoS One,9(3): e91167.
    显示于类别:[生物科技學系] 期刊論文

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