Induction of Apoptosis in Human DU145 Prostate Cancer Cells by KHC-4 Treatment

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题名:	Induction of Apoptosis in Human DU145 Prostate Cancer Cells by KHC-4 Treatment
作者:	Tien-Huang Lin;Wen-Chi Chen;Hsi-Chin Wu;Wen-Shin Chien;Shang-Seu Lee;Fu-Jenn Tsai;Chang-Hai Tsai;Wei-Jen Ting;Sheng-Chu Kuo;Chih-Yang Huang
贡献者:	生物科技學系
关键词:	anti-tumor effects;apoptosis;2’-fluoro-6-morpholinyl-2-phenyl-4-quinolone;prostate cancer
日期:	2014-04
上传时间:	2014-06-05 03:48:00 (UTC+0)
摘要:	Prostate cancer (CaP) is one of the most prevalent cancers worldwide and the incidence and mortality rates have been rapidly increasing in recent years in Taiwan. Therefore, it is important to development anti-cancer therapy. In this study, KHC-4 was identified from 2-phenyl-4-quionolone derivatives in human prostate cancer cells and as a potential antitumor agent. In this study, we have identified KHC-4 induced apoptosis effects in castration-resistant prostate cancer DU145 cells, and the IC50 value of KHC-4 was 0.1 μM. KHC-4 suppressed the survival signaling p-PI3K and p-Akt and protein levels of Bcl-2 and Bcl-xL, upregulated Bax, cytochrome c and caspase 8/9 and induced apoptosis by mitochondrial-dependent pathway. In JC-1 assay monitored the loss of membrane potential in KHC-4 treatments. TUNEL assay results showed DNA fragmentation in KHC-4 induced apoptosis.We concluded that KHC-4 exerted anti-tumor effects in DU145 cells by induction of apoptosis.
關聯:	CHINESE JOURNAL OF PHYSIOLOGY,57(2):99-104.
显示于类别:	[國際企業學系] 期刊論文

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