Disturbance of A. thaliana microRNA-regulated pathways by Xcc bacterial effector proteins

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題名:	Disturbance of A. thaliana microRNA-regulated pathways by Xcc bacterial effector proteins
作者:	Nilubon;Kurubanjerdjit, Nilubon;蔡進發;JEFFREY, J.P.TSAI;黃建宏;Huang, Chien-Hung;吳家樂;Ng, Ka-Lok
貢獻者:	生物與醫學資訊學系
日期:	2014-04
上傳時間:	2014-06-05 03:05:34 (UTC+0)
摘要:	Plants are continuously subjected to infection by pathogens, including bacteria and viruses. Bacteria can inject a variety of effector proteins into the host to reprogram host defense mechanism. It is known that microRNAs participate in plant disease resistance to bacterial pathogens and previous studies have suggested that some bacterial effectors have evolved to disturb the host's microRNA-regulated pathways; and so enabling infection. In this study, the inter-species interaction between an Xanthomonas campestris pv campestris (Xcc) pathogen effector and Arabidopsis thaliana microRNA transcription promoter was investigated using three methods: (1) interolog, (2) alignment based on using transcription factor binding site profile matrix, and (3) the web-based binding site prediction tool, PATSER. Furthermore, we integrated another two data sets from our previous study into the present web-based system. These are (1) microRNA target genes and their downstream effects mediated by protein-protein interaction (PPI), and (2) the Xcc-Arabidopsis PPI information. This present work is probably the first comprehensive study of constructing pathways that comprises effector, microRNA, target genes and PPI for the study of pathogen-host interactions. It is expected that this study may help to elucidate the role of pathogen-host interplay in a plant's immune system. The database is freely accessible at: http://ppi.bioinfo.asia.edu.tw/EDMRP .
關聯:	AMINO ACIDS
顯示於類別:	[生物資訊與醫學工程學系 ] 期刊論文

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