RC-6 ribonuclease induces caspase activation, cellular senescence and neuron-like morphology in NT2 embryonal carcinoma cells.

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Title:	RC-6 ribonuclease induces caspase activation, cellular senescence and neuron-like morphology in NT2 embryonal carcinoma cells.
Authors:	Yiang, GT;Yiang, GT;Tsai, HF;Tsai, HF;Chen, JR;Chen, JR;Chou, PL;Chou, PL;Wu, TK;Wu, TK;Liu, HC;Liu, HC;Chang, WJ;Chang, WJ;Liu, LC;Liu, LC;Tseng, HH;Tseng, HH;余永倫
Contributors:	生物科技學系
Date:	2014-04
Issue Date:	2014-06-04 02:22:24 (UTC+0)
Abstract:	Frog ribonucleases have been demonstrated to have anticancer activities. However, whether RC-6 ribonuclease exerts anticancer activity on human embryonal carcinoma cells remains unclear. In the present study, RC-6 induced cytotoxicity in NT2 cells (a human embryonal carcinoma cell line) and our studies showed that RC-6 can exert anticancer effects and induce caspase-9 and -3 activities. Moreover, to date, there is no evidence that frog ribonuclease-induced cytotoxicity effects are related to cellular senescence. Therefore, our studies showed that RC-6 can increase p16 and p21 protein levels and induce cellular senescence in NT2 cells. Notably, similar to retinoic acid-differentiated NT2 cells, neuron-like morphology was found on some remaining live cells after RC-6 treatment. In conclusion, our study is the first to demonstrate that RC-6 can induce cytotoxic effects, caspase-9/-3 activities, cellular senescence and neuron-like morphology in NT2 cells.
Relation:	ONCOLOGY REPORTS,31(4):1738-44
Appears in Collections:	[生物科技學系] 期刊論文

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