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    题名: High-resolution melting analyses for genetic variants in ARID5B and IKZF1 with childhood acute lymphoblastic leukemia susceptibility loci in Taiwan
    作者: Lin, Chien-Yu;Lin, Chien-Yu;Li, Meng-Ju;Li, Meng-Ju;Ch, Jan-Gowth;Chang, Jan-Gowth;Liu, Su-Ching;Liu, Su-Ching;Weng, Tefu;Weng, Tefu;Wu, Kang-Hsi;Wu, Kang-Hsi;Yang, Shu-Fen;Yang, Shu-Fen;Huan, Fu-Kuei;Huang, Fu-Kuei;Lo, Wan-Yu;Lo, Wan-Yu;彭慶添;Peng, Ching-Tien
    贡献者: 生物科技學系
    关键词: ARID5B;Childhood acute lymphoblastic leukemia;High-resolution melting analyses;IKZF1;Single nucleotide polymorphisms
    日期: 2014-02
    上传时间: 2014-06-04 02:19:45 (UTC+0)
    摘要: Background
    Childhood acute lymphoblastic leukemia (ALL), a heterogeneous disease that includes multiple subtypes is defined by cell lineage and chromosome anomalies. Previous genome-wide association studies have reported several ARID5B and IKZF1 single nucleotide polymorphisms (SNPs) associated with the incidence of ALL. High-resolution melting (HRM) analysis is a rapid and convenient technique to detect SNPs; we thereby detected SNPs in ARID5B and IKZF1 genes.

    Methods
    We enrolled 79 pediatric ALL patients and 80 healthy controls. Polymorphic variants of IKZF1 (rs6964823, rs4132601, and rs6944602) and ARID5B (rs7073837, rs10740055, and rs7089424) were detected by HRM, and SNPs were analyzed for association with childhood ALL.

    Results
    The distribution of genotype rs7073837 in ARID5B significantly differed between ALL and controls (P = 0.046), while those of IKZF1 (rs6964823, rs4132601, and rs6944602) and ARID5B (rs10740055 and rs7089424) did not. We analyzed the association for SNPs with B lineage ALL to find rs7073837 in ARID5B, conferring a higher risk for B lineage ALL (odds ratio, OR = 1.70, 95% confidence interval, CI = 1.01–2.87, P = 0.049).

    Conclusion
    HRM is a practical method to detect SNPs in ARID5B and IKZF1 genes. We found that rs7073837 in ARID5B correlated with a risk for childhood B lineage ALL.
    關聯: BLOOD CELLS MOLECULES AND DISEASES, V.52 N.2–3:140–145.
    显示于类别:[生物科技學系] 期刊論文

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