Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts.

ASIAIR > College of Medical and Health Science > Department of Biotechnology > Journal Article > Item 310904400/79541

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Title:	Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts.
Authors:	李信達;Lee, Shin-Da;郭薇雯;Kuo, Wei-Wen;Fan, Ming-Jen;Fan, Ming-Jen;Lin, Yueh-Min;Lin, Yueh-Min;Hu, Wei-Syun;Hu, Wei-Syun;Hua, Yi-Ching;Huang, Yi-Ching;V.Bharath, K;Kumar, V.Bharath;蔡輔仁;Tsai, Fuu-Jen;蔡長海;黃志揚;HUANG, CHIH-YANG
Contributors:	生物科技學系
Keywords:	Heart;Fas receptor;Caspase;Mitochondrial;Cell death;Hypertension
Date:	2014-02
Issue Date:	2014-06-04 02:13:53 (UTC+0)
Abstract:	Cardiac apoptosis was found in hearts from hypertensive animals, therefore in this study we aimed to evaluate the anti-apoptotic and pro-survival effects of protocatechuic acid (PCA) on hypertensive hearts. At first we found that, sedentary group (SHR)-PCA group’s decreased TUNEL-positive apoptotic cells than SHR group alone. Protein levels of Fas ligand, Fas death receptor, Fas-associated death domain (FADD), Bid, t-Bid, Bax, cytochrome c, activated caspase-8, activated caspase 9 and activated caspase-3 were decreased in SHR-PCA group compared with SHR group. Moreover, SHR-PCA groups increased pro-survival pathway proteins like IGF1, pIGF1R, pPI3K, p-Akt, Bcl-xL, and Bcl-2 than SHR and sedentary normotensive group (WKY). All these finding suggest us that, Protocatechuic acid prevented hypertension-enhanced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways and enhanced cardiac pro-survival pathway in rat models.
Relation:	CHEMICO-BIOLOGICAL INTERACTIONS, V.209 (25):77–84.
Appears in Collections:	[Department of Biotechnology] Journal Article

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