GABA Tea Prevents Cardiac Fibrosis by Attenuating TNF-alpha and Fas/FasL-mediated apoptosis in Streptozotocin-Induced Diabetic Rats

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題名:	GABA Tea Prevents Cardiac Fibrosis by Attenuating TNF-alpha and Fas/FasL-mediated apoptosis in Streptozotocin-Induced Diabetic Rats
作者:	Shur-Hueih, C;Cherng, Shur-Hueih;黃志揚;HUANG, CHIH-YANG;Kuo, Wei-Wen;Kuo, Wei-Wen;Lai, Shue-Er;Lai, Shue-Er;Tse, Chien-Yu;Tseng, Chien-Yu;Lin, Yueh-Min;Lin, Yueh-Min;蔡輔仁;Tsai, Fuu-Jen;Hsueh-Fang, W;Wang, Hsueh-Fang
貢獻者:	生物科技學系
關鍵詞:	Diabetes;Fas;GABA tea;Heart;TNF-alpha
日期:	2014-03
上傳時間:	2014-06-04 02:12:44 (UTC+0)
摘要:	GABA tea is a tea product that contains a high level of gamma-aminobutyric acid (GABA). This study investigated the effects of GABA tea on the heart in a diabetic rat model. Male Wistar rats were injected with 55mg/kg streptozotocin (STZ) to induce diabetes for 2weeks and then orally given dosages of 4.55 and 45.5mg/kg/day GABA tea extract for 6weeks. The results revealed that fasting blood glucose levels returned to normal levels in GABA tea-treated diabetic rats, but not in the untreated diabetic rats. Additionally, GABA tea effectively inhibited cardiac fibrosis induced by STZ. Further experiments showed that the STZ-induced protein levels of tumor necrosis factor-alpha (TNF-alpha), Fas, activated caspase-8 and caspase-3 were significantly inhibited by the GABA tea treatment. Therefore, our data suggest that the inhibiting effect of GABA tea on STZ-induced cardiac fibrosis in diabetic rats may be mediated by reducing blood glucose and further attenuating TNF-alpha expression and/or Fas/Fas ligand (FasL)-mediated apoptosis. These findings will provide implications for the potential anti-diabetic properties of GABA tea.
關聯:	FOOD AND CHEMICAL TOXICOLOGY
顯示於類別:	[生物科技學系] 期刊論文

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