Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/79187

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Title:	Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts
Authors:	鄧正賢;Deng, Jeng-Shyan;范宗宸;Fan, Chung-Chen
Contributors:	保健營養生技學系
Keywords:	Caspase;Cell death;Fas receptor;Heart;Hypertension;Mitochondrial
Date:	201312
Issue Date:	2014-01-06 12:20:04 (UTC+0)
Abstract:	Cardiac apoptosis was found in hearts from hypertensive animals, therefore in this study we aimed to evaluate the anti-apoptotic and pro-survival effects of protocatechuic acid (PCA) on hypertensive hearts. At first we found that, sedentary group (SHR)-PCA group's decreased TUNEL-positive apoptotic cells than SHR group alone. Protein levels of Fas ligand, Fas death receptor, Fas-associated death domain (FADD), Bid, t-Bid, Bax, cytochrome c, activated caspase-8, activated caspase 9 and activated caspase-3 were decreased in SHR-PCA group compared with SHR group. Moreover, SHR-PCA groups increased pro-survival pathway proteins like IGF1, pIGF1R, pPI3K, p-Akt, Bcl-xL, and Bcl-2 than SHR and sedentary normotensive group (WKY). All these finding suggest us that, Protocatechuic acid prevented hypertension-enhanced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways and enhanced cardiac pro-survival pathway in rat models.
Relation:	CHEMICO-BIOLOGICAL INTERACTIONS ;209:77-84
Appears in Collections:	[食品營養與保健生技學系] 期刊論文

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