CYP17 and tumor necrosis factor-α gene polymorphisms are associated with risk of oral cancer in Chinese patients in Taiwan

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Title:	CYP17 and tumor necrosis factor-α gene polymorphisms are associated with risk of oral cancer in Chinese patients in Taiwan
Authors:	陳威成;Ming-Hsui Tsai;Lei Wan;Chen Wen-Chi;Chang-Hai Tsai;Fuu-Jen Tsai
Date:	2005-01
Issue Date:	2009-12-23 06:22:14 (UTC+0)
Publisher:	Asia University
Abstract:	Objective Cancer of the oral cavity is the most commonly seen malignancy in Taiwan, and its rising incidence poses a formidable challenge to oncologists. The CYP17 gene encodes P450c17alpha, an enzyme involved in the metabolism of steroid hormones. Tumor necrosis factor-α (TNF-α) is one of the cytokines produced by macrophages, and its function has been postulated to play a role in cancer formation. We investigated whether polymorphisms of CYP17 and TNF-α genes are associated with oral cancer.
Relation:	ACTA OTO-LARYNGOLOGICA 125 (1): 96-99
Appears in Collections:	[College of Medical and Health Science] Journal Article

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