ASIA unversity:Item 310904400/6750
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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6750


    Title: Simultaneously Evaluating the Effects of One-week Fluticasone Propionate Inhalation Therapy on Lung Ventilation and Permeability in Children with Asthma
    Authors: An-Chyi Chen;Fuu-Jen Tsai;Chang-Hai Tsai;Cheng-Chieh Lin;Cheng-Chun Lee;Chia-Hung Kao
    Date: 2003
    Issue Date: 2009-12-23 06:22:02 (UTC+0)
    Publisher: Asia University
    Abstract: This study evaluated the effects of fluticasone propionate inhalation therapy on lung ventilation and alveolar permeability by quantitative Tc-99m DTPA radioaerosol inhalation lung scintigraphy in 15 children with asthma. Lung ventilation was evaluated as the distribution percentage (D%) of Tc-99m DTPA radioaerosols in the central, intermediate and peripheral regions of the right lung. Alveolar permeability was measured by the rate of Tc-99m DTPA radioaerosol clearance curve from the peripheral alveoli of the right lung and represented as slope. The D% and slopes were calculated before and after one-week inhalation therapy (100 ?g fluticasone propionate two times daily for one-week) to evaluate the effects of inhalation therapy on lung ventilation and alveolar permeability. The preliminary results revealed statistically significantly improved lung ventilation but no significant change of alveolar permeability in the right lung after one-week fluticasone propionate inhalation therapy in children with asthma. We suggest that the widely available and noninvasive Tc-99m DTPA radioaerosol inhalation lung scintigraphy can simultaneously evaluate lung ventilation and alveolar permeability in one study and should contribute to any disorder involving both alveoli and airways.
    Relation: MITTEILUNGEN DER OSTERREICHISCHEN GEOGRAPHISCHEN GESELLSCHAFT 181 (5): 283-289
    Appears in Collections:[College of Medical and Health Science] Journal Article

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