Mutation analysis of a family with hereditary hemorrhagic telangiectasia associated with hepatic arteriovenous malformation

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題名:	Mutation analysis of a family with hereditary hemorrhagic telangiectasia associated with hepatic arteriovenous malformation
作者:	Wei-De Lin;Wu,Jer-Yuarn;Tsai,Fuu-Jen;Lee,Chun-Cheng;Chang-Hai Tsai
日期:	2001-12
上傳時間:	2009-12-23 06:21:30 (UTC+0)
出版者:	Asia University
摘要:	Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by multisystemic vascular dysplasia. Two related genes, endoglin and activin receptor-like kinase (ALK-1), have been mapped to chromosomes 9q34 and 12q13, respectively. We describe a Taiwanese HHT family with hepatic arteriovenous malformation. Clinical and molecular evaluations were performed in eight members of this family, and HHT symptoms were found in three adults. Short tandem repeat markers were used to perform linkage analysis, and this family was classified as HHT type 2 (ALK-1 gene). The exons of ALK-1 were amplified using the polymerase chain reaction and subjected to direct DNA sequencing. The mutation causing the disease was located at ALK-1 codon 411, causing an arginine to glutamine substitution. Five members of this family carried the mutated ALK-1 gene. This investigation successfully used linkage and sequencing techniques to perform molecular diagnosis of HHT.
關聯:	JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 100 (12): 817-819
顯示於類別:	[醫學暨健康學院] 期刊論文

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