Association of GABRG2 Polymorphisms with Idiopathic Generalized Epilepsy

ASIA unversity > 醫學暨健康學院 > 期刊論文 > Item 310904400/6658

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题名:	Association of GABRG2 Polymorphisms with Idiopathic Generalized Epilepsy
作者:	I-Ching Chou;Lee,Chun-Cheng;Chang-Hai Tsai;Yuhsin Tsai;Lei Wan;Yu-An Hsu;Tsai-Chung Li;Tsai,Fuu-Jen
日期:	2007-01
上传时间:	2009-12-23 06:21:20 (UTC+0)
出版者:	Asia University
摘要:	Missense mutations in the γ2 subunit of γ-aminobutyric acid (GABA) receptor gene have recently been described in families with idiopathic generalized epilepsies. This study aimed to evaluate whether polymorphisms of the γ2 subunit of the GABA receptor gene are associated with idiopathic generalized epilepsies. A total of 77 children with idiopathic generalized epilepsies and 83 normal control subjects were included in the study. Polymerase chain reaction was used to identify the C/T and A/G polymorphisms of the γ2 subunit of the GABA receptor gene on chromosome 5q33. Genotypes and allelic frequencies in both groups were compared. The γ2 subunit of the GABA receptor (nucleotide position 3145 in intron G-> A) gene in both groups was not significantly different. In contrast, the γ2 subunit of GABA receptor (SNP211037)-C allele frequency in patients with idiopathic generalized epilepsies was significantly higher than that in healthy control subjects (P = 0.002). The odds ratio for developing idiopathic generalized epilepsies in individuals with the γ2 subunit of the GABA receptor (SNP211037)-C/C genotype was 3.61 compared with individuals with the γ2 subunit of the GABA receptor (SNP211037)-T/T genotype. These data suggest that the γ2 subunit of the GABA receptor gene might be one of the susceptibility factors for idiopathic generalized epilepsies.
關聯:	PEDIATRIC NEUROLOGY 36 (1): 40-44
显示于类别:	[醫學暨健康學院] 期刊論文

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