Association of the nicotinic receptor beta 2 subunit and febrile seizures

ASIA unversity > 醫學暨健康學院 > 期刊論文 > Item 310904400/6631

請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/6631

題名:	Association of the nicotinic receptor beta 2 subunit and febrile seizures
作者:	Ching-Tien Peng;I-Ching Chou;Chia-Ing Li;Yu-An Hsu;Chang-Hai Tsai;Fuu-Jen Tsai
日期:	2004
上傳時間:	2009-12-23 06:21:08 (UTC+0)
出版者:	Asia University
摘要:	The nicotinic acetylcholine receptors are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Mutations in neuronal nicotinic acetylcholine receptor beta 2 subunit have been associated with autosomal dominant nocturnal frontal lobe epilepsies. A major challenge is to establish whether the monogenic epilepsy gene also contributes to the common epilepsies. Because febrile seizures represent the majority of childhood seizures, and a genetic predisposition, we investigated the possibility that the nicotinic acetylcholine receptor beta 2 subunit might be involved in the etiology of febrile seizures. Children were divided into two groups: those with febrile seizures (group 1; N = 104) and control patients (group 2; N = 83). Polymerase chain reaction was used to identify the G/C and T/C polymorphisms of the nicotinic acetylcholine receptor beta 2 subunit gene, which is mapped on chromosome 1. Genotypes and allelic frequencies for nicotinic acetylcholine receptor beta 2 subunit gene polymorphisms in both groups were compared. The results indicated that genotypes and allelic frequencies in both groups were not significantly different. These data suggest that nicotinic acetylcholine receptor beta 2 subunit polymorphisms are not a useful marker for prediction of the susceptibility to febrile seizures.
關聯:	PEDIATRIC NEUROLOGY 30 (3): 186-189
顯示於類別:	[醫學暨健康學院] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
	0Kb	Unknown	634	檢視/開啟

在ASIAIR中所有的資料項目都受到原著作權保護.

資料載入中.....