Epidermal Growth Factor Receptor(EGFR) gene Bsr I Polymorphism Is Associated with Systemic Lupus Erythematosus

ASIA unversity > 醫學暨健康學院 > 期刊論文 > Item 310904400/6621

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/6621

题名:	Epidermal Growth Factor Receptor(EGFR) gene Bsr I Polymorphism Is Associated with Systemic Lupus Erythematosus
作者:	Chung-Ming Huang;Chang-Hai Tsai;Chi-Lan Chen;chin-ping Chang;Lai,Chien-Chen;Tsai,Fuu-Jen
日期:	2004
上传时间:	2009-12-23 06:21:03 (UTC+0)
出版者:	Asia University
摘要:	The purpose of this study was to determine if epidermal growth factor receptor (EGFR) gene polymorphism was a marker of susceptibility to or severity of Chinese patients with systemic lupus erythematosus (SLE) in Taiwan. The study included 119 Chinese patients with SLE. One hundred unrelated healthy individuals living in central Taiwan served as control subjects. Polymorphisms of the EGFR Bsr I gene were typed from genomic DNA. The genotypes, allelic frequencies and carriage rates were compared between SLE patients and control subjects. The relationship between allelic frequencies and clinical manifestations of SLE was evaluated. For the genotype of EGFR gene Bsr I polymorphism, there was statistically significant differences between the SLE and control groups (chi-squared test, P = 0.009, 2= 9.21). In addition, there was significant association between the two groups in allelic frequency of the T allele (P = 0.02, 2= 5.27). However, we did not detect any association between EGFR genotype and clinical or laboratory profiles in SLE patients. The results suggest that the EGFR gene Bsr I polymorphism is related to SLE.
關聯:	LUPUS (13): 773-776
显示于类别:	[醫學暨健康學院] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	0Kb	Unknown	531	检视/开启

在ASIAIR中所有的数据项都受到原著作权保护.

数据加载中.....