Genistein Suppresses the Isoproterenol-Treated H9c2 Cardiomyoblast Cell Apoptosis Associated with P-38, Erk1/2, JNK, and NF-keppa B Signaling Protein Activation

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题名:	Genistein Suppresses the Isoproterenol-Treated H9c2 Cardiomyoblast Cell Apoptosis Associated with P-38, Erk1/2, JNK, and NF-keppa B Signaling Protein Activation
作者:	Hu, Wei-Syun;Hu, Wei-Syun;Lin, Yueh-Min;Lin, Yueh-Min;Tsung-Jung, H;Ho, Tsung-Jung;Che, Ray-Jade;Chen, Ray-Jade;Li, Yi-Hui;Li, Yi-Hui;蔡輔仁;Tsai, Fuu-Jen;Hsua, 蔡長海、Cecilia;Day, Cecilia Hsuan;Tung-Sheng, C;Chen, Tung-Sheng;黃志揚;HUANG, CHIH-YANG
贡献者:	健康產業管理學系
日期:	2013-10
上传时间:	2013-12-06 06:52:30 (UTC+0)
摘要:	Heart disease (HD) is associated with estrogen and therefore gender and menopausal status. In addition, clinical evidence shows that increased serum norepinephrine is found in patients with HD. Therefore, this study aimed to investigate the cardio-protective effect of genistein, a selective estrogen receptor modulator (SERM) from soy bean extract, in H9c2 cardiomyoblast cells treated with isoproterenol (ISO), a norepinephrine analog. In this in vitro model, image data and results from western blotting shown that ISO treatment was capable of inducing cellular apoptosis, especially the mitochondrial dependent pathway. Treatment of genistein could suppress the expression of mitochondrial pro-apoptotic proteins including Bad, caspase-8, caspase-9, and caspase-3 in H9c2 treated with ISO. By contrast, several survival proteins were expressed in H9c2 treated with genistein, such as phosphor (p)-Akt, p-Bad, and p-Erk1/2. Furthermore, we confirmed that the protective role of genistein was partially mediated through the expression of Erk1/2, Akt, and NF κ B proteins by adding several pathway inhibitors. These in vitro data suggest that genistein may be a safe and natural SERM alternative to hormone therapy in cardio-protection.
關聯:	The American journal of Chinese medicine,41(5):1125-1136
显示于类别:	[健康產業管理學系] 期刊論文

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