Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells

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Title:	Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells
Authors:	Chou, CT;Lin, WF;Kong, ZL;Chen, SY;Hwang, DF
Contributors:	保健營養生技學系
Keywords:	Arsenite;Taurine;NDRG-4;BDNF;SIRT-1;Neurotrophic
Date:	2013-11
Issue Date:	2013-12-06 06:51:49 (UTC+0)
Abstract:	The study investigated the effect of taurine on cell viability and neurotrophic gene expression in arsenite-treated human neuroblastoma SH-SY5Y cells. Arsenite-induced intracellular reactive oxygen species (ROS) and interrupted cell cycle in SH-SY5Y cells. In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells. In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters.
Relation:	AMINO ACIDS, 45(4):811-819.
Appears in Collections:	[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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