Probiotic-fermented purple sweet potato yogurt activates compensatory IGF-IR/PI3K/Akt survival pathways and attenuates cardiac apoptosis in the hearts of spontaneously hypertensive rats

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Title:	Probiotic-fermented purple sweet potato yogurt activates compensatory IGF-IR/PI3K/Akt survival pathways and attenuates cardiac apoptosis in the hearts of spontaneously hypertensive rats
Authors:	LIN, PEI-PEI;LIN, PEI-PEI;HSI, YOU-MIIN;HSIEH, YOU-MIIN;Kuo, Wei-Wen;Kuo, Wei-Wen;LIN, YUEH-MIN;LIN, YUEH-MIN;YEH, YU-LAN;YEH, YU-LAN;CHIEN-CHUNG;LIN, CHIEN-CHUNG;蔡輔仁;Tsai, Fuu-Jen;蔡長海、黃志揚;HUANG, CHIH-YANG;CHENG-CHIH, T;TSAI, CHENG-CHIH
Contributors:	生物科技學系
Date:	2013-10
Issue Date:	2013-12-06 06:44:44 (UTC+0)
Abstract:	Apoptosis is recognized as a predictor of adverse outcomes in subjects with cardiac diseases. The aim of this study was to explore the effects of probiotic-fermented purple sweet potato yogurt (PSPY) with high γ-aminobutyric acid (GABA) content on cardiac apoptosis in spontaneously hypertensive rat (SHR) hearts. The rats were orally adminsitered with 2 different concentrations of PSPY (10 and 100%) or captopril, 15.6 mg/kg, body weight (BW)/day. The control group was administered distilled water. DAPI and TUNEL staining were used to detect the numbers of apoptotic cells. A decrease in the number of TUNEL-positive cardiac myocytes was observed in the SHR-PSPY (10 and 100%) groups. In addition, the levels of key components of the Fas receptor- and mitochondrial-dependent apoptotic pathways were determined by western blot analysis. The results revealed that the levels of the key components of the Fas receptor- and mitochondrial-dependent apoptotic pathway were significantly decreased in the SHR-captopril, and 10 and 100% PSPY groups. Additionally, the levels of phosphorylated insulin-like growth factor‑I receptor (p-IGF‑IR) were increased in SHR hearts from the SHR-control group; however, no recovery in the levels of downstream signaling components was observed. In addition, the levels of components of the compensatory IGF-IR-dependent survival pathway (p-PI3K and p-Akt) were all highly enhanced in the left ventricles in the hearts form the SHR-10 and 100% PSPY groups. Therefore, the oral administration of PSPY may attenuate cardiomyocyte apoptosis in SHR hearts by activating IGF‑IR-dependent survival signaling pathways.
Relation:	INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE;32(6):1319-28.
Appears in Collections:	[生物科技學系] 期刊論文

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