Toll-like receptor 9 SNPs are susceptible to the development and progression of membranous glomerulonephritis: 27 years follow up in Taiwan

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题名:	Toll-like receptor 9 SNPs are susceptible to the development and progression of membranous glomerulonephritis: 27 years follow up in Taiwan
作者:	Chen, Yng-Tay;Chen, Yng-Tay;Chang-Ching;Wei, Chang-Ching;吳家樂;Ng, Ka-Lok;Ch, Cheng-Hsu;Chen, Cheng-Hsu;Ch, Chia-Jung;Chan, Chia-Jung;Che, Xian-Xiu;Chen, Xian-Xiu;Cha, Yuan-Yen;Chang, Yuan-Yen;Che, Shih-Yin;Chen, Shih-Yin;Tsai, Fuu-Jen;Tsai, Fuu-Jen
贡献者:	生物與醫學資訊學系
日期:	2013-08
上传时间:	2013-10-29 09:36:42 (UTC+0)
摘要:	Abstract The purpose of this study was to determine whether toll-like receptors 9 (TLR9) gene polymorphisms (rs352139 and rs352140) were markers of susceptibility to the development and progression of membranous nephropathy (MGN) in Taiwanese patients. The polymorphisms were investigated by polymerase chain reaction in 397 Taiwanese individuals (134 MGN patients and 263 controls). Patients with malignancy, chronic infectious diseases, lupus nephritis, or drug-induced secondary MGN were excluded from the study. Data showed AA genotype at rs352139 SNP or GG genotype at rs352140 SNP may indicate higher risk for MGN (odds ratio [OR] = 1.55; 95% confidence interval [CI] = 1.02-2.35, at rs352139 SNP; OR = 1.57; 95% CI = 1.03-2.39, at rs352140 SNP). However, MGN patients with A-G haplotype were susceptible for decreased creatinine clearance rate and for seriously tubule-interstitial fibrosis. The result suggests for the first time that TLR9 (rs352139 and rs352140) polymorphisms may contribute to the development and progression of MGN.
關聯:	RENAL FAILURE, 35(10):1370-5.
显示于类别:	[生物資訊與醫學工程學系 ] 期刊論文

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