Porous Alginate/Hydroxyapatite Composite Scaffolds for Bone Tissue Engineering

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Title:	Porous Alginate/Hydroxyapatite Composite Scaffolds for Bone Tissue Engineering
Authors:	Hong-Ru Lin;Yu-Jen Yeh;Chun-Jung Kuo;C. Y. Yang;Yu -Jun Wu;Yiu-Jiuan Lin
Contributors:	Department of Applied Chemistry, Chia Nan University of Pharmacy and Science, Tainan, Taiwan;Institute of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan;Department of Osteopathy, National Cheng Kung University Medical College, Tainan, Taiwan;Institute of Biotechnology, National Cheng Kung University, Tainan, Taiwan;Department of Nursing, Chung Hwa College of Medical Technology, Taiwan, Taiwan;Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
Keywords:	Tissue engineering;Biodegradable polymers;Scaffolds;Alginate;Hydroxyapatite;and Cell culture
Date:	2003-09-13
Issue Date:	2009-12-09 05:25:17 (UTC+0)
Publisher:	臺中健康暨管理學院
Abstract:	In this paper, a series of alginate/hydroxyapatite (HAP) composite scaffolds were prepared and characterized. HAP was incorporated into the alginate gel solution to improve the mechanical properties and biocompatibility of scaffolds. The scaffold was prepared by a three-step procedure: first gelation of the alginate solution to form a hydrogel with divalent cations (such as Ca2＋, Sr2＋and Ba2＋), then freezing, and finally drying by lyophilization to produce a three-dimensional, porous sponge. Alginate/HAP composite scaffolds prepared in this paper not only have well interconnected, highly porous structure but also have greater mechanical properties than the neat alginate scaffold. The morphology of scaffolds can be manipulated by tuning the quenching temperature during the preparation. The degradation behavior of alginate/HAP composite scaffolds was easy to control through the pretreatment by immersing scaffolds into 1.0 M CaCl2 solution. Osteoblastic-like cell line, UMR-106, seeded into the alginate/HAP composite scaffolds demonstrated better biocompatibility than the pure one. These natural polymeric sponges fabricated in this article may be a promising approach for tissue engineering applications.
Relation:	第六屆工程科技與中西醫學應用研討會 452-458
Appears in Collections:	[行動商務與多媒體應用學系] 會議論文

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