Due to the great difference of psd(power spectral density) between normal persons and patients, the spectrum analysis of the blood pressure wave(BPW) of artery at hand, i.e. the diagnosis pulse of Chinese Medicine, is presented in this paper. Therefore, it is inevitable to compare the various methods of psd estimation such as periodogram, Welch, Burg and Yule-Walker. Finally, the transfer function which is an important frequency characteristic between input-output relation is calculated and shows some specific feature among healthy and illness persons.