The role of the VEGF-C/VEGFR-3 axis in cancer progression

ASIAIR > College of Medical and Health Science > Department of Biotechnology > Journal Article > Item 310904400/4645

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4645

Title:	The role of the VEGF-C/VEGFR-3 axis in cancer progression
Authors:	J-L Su;C-J Yen;P-S Chen;S-E Chuang;C-C Hong;I-H Kuo;H-Y Chen;M-C Hung;M-L Kuo
Keywords:	VEGF-C;VEGFR-3;lymphangiogenesis;metastasis
Date:	2007-02
Issue Date:	2009-11-30 07:57:55 (UTC+0)
Publisher:	Asia University
Abstract:	Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.
Relation:	BRITISH JOURNAL OF CANCER 96 (4): 541-545
Appears in Collections:	[Department of Biotechnology] Journal Article

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