Crossregulation of NF-KB by the APC/GSK-3beta/beta-catenin pathway

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/4631

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题名:	Crossregulation of NF-KB by the APC/GSK-3beta/beta-catenin pathway
作者:	Deng, J.;Xia, W.;Miller, S. A.;Wen, Y.;Wang, H.;Mien-Chie Hung
关键词:	APC;GSK-3;-catenin;NF-B;breast cancer
日期:	2004-03
上传时间:	2009-11-27 05:57:09 (UTC+0)
出版者:	Asia University
摘要:	Glycogen synthase kinase-3 (GSK-3) and adenomatous polyposis coli (APC) play an important role in the regulation of -catenin. Inhibition of or defects in their functions can lead to activation of -catenin. -catenin has been recently found to interact with and inhibit nuclear factor kappa B (NF-B). However, the regulatory roles of GSK-3/APC on the NF-B signaling pathway are unknown because of their diverse effects. In this study, we investigated whether GSK-3/APC might regulate NF-B activity through -catenin. We found that inhibition of GSK-3 suppressed NF-B activity, whereas reexpression of APC restored NF-B activity in APC mutated cells. The regulatory effects were through -catenin because depletion of -catenin with small interfering RNA (siRNA) in the same systems reversed the effects. The regulatory relationship was further supported by the analysis of primary breast tumor tissues in vivo in which NF-B target TRAF1 was inversely correlated with activated -catenin. Thus, APC/GSK-3, through -catenin, may crossregulate NF-B signaling pathway.
關聯:	MOLECULAR CARCINOGENESIS 39(3):139-146
显示于类别:	[生物科技學系] 期刊論文

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