Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

ASIAIR > College of Medical and Health Science > Department of Biotechnology > Journal Article > Item 310904400/4621

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4621

Title:	Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
Authors:	Li, Y. M.;Pan, Y.;Wei, Y.;Cheng, X.;Zhou, B.;Tan, M.;Zhou, X.;Xia, W.;Hortobagyi, G. N.;Yu, D.;Mien-Chie Hung
Date:	2004-11
Issue Date:	2009-11-27 05:57:06 (UTC+0)
Publisher:	Asia University
Abstract:	The receptor tyrosine kinase HER2 enhances tumor metastasis; however, its role in homing to metastatic organs is poorly understood. The chemokine receptor CXCR4 has recently been shown to mediate the movement of malignant cancer cells to specific organs. Here, we show that HER2 enhances the expression of CXCR4, which is required for HER2-mediated invasion in vitro and lung metastasis in vivo. HER2 also inhibits ligand-induced CXCR4 degradation. Finally, a significant correlation between HER2 and CXCR4 expression was observed in human breast tumor tissues, and CXCR4 expression correlated with a poor overall survival rate in patients with breast cancer. These results provide a plausible mechanism for HER2-mediated breast tumor metastasis and establish a functional link between HER2 and CXCR4 signaling pathways.
Relation:	CANCER CELL 6(5):459-469
Appears in Collections:	[Department of Biotechnology] Journal Article

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