The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells

ASIAIR > College of Medical and Health Science > Department of Biotechnology > Journal Article > Item 310904400/4597

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/4597

Title:	The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
Authors:	Jen-Liang Su;Pan-Chyr Yang;Jin-Yuan Shih;Ching-Yao Yang;Lin-Hung Wei;Chang-Yao Hsieh;Chia-Hung Chou;Yung-Ming Jeng;Ming-Yang Wang;King-Jen Chang;Mien-Chie Hung;Kuo, M-L.
Date:	2006-03
Issue Date:	2009-11-27 05:57:00 (UTC+0)
Publisher:	Asia University
Abstract:	Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis. This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell metastasis. VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin-1 through activation of the Src-p38 MAPK-C/EBP-dependent pathway. Examination of tumor tissues from various types of cancers revealed high levels of Flt-4 and VEGF-C expression that correlated closely with clinical metastasis and patient survival. The VEGF-C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells.
Relation:	CANCER CELL 9(3):209-223
Appears in Collections:	[Department of Biotechnology] Journal Article

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