Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/4586

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題名:	Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models
作者:	Xie, X.;Xia, W.;Li, Z.;Kuo, H-P.;Liu, Y.;Li, Z.;Ding, Q.;Zhang, S.;Spohn, W.;Yang, Y.;Wei, Y.;Lang, J-Y.;Evans, D. B.;Chiao, P. J.;Abbruzzese, J. L.;Mien-Chie Hung
日期:	2007
上傳時間:	2009-11-27 05:56:57 (UTC+0)
出版者:	Asia University
摘要:	Pancreatic cancer is an aggressive malignancy with morbidity rates almost equal to mortality rates because of the current lack of effective treatment options. Here, we describe a targeted approach to treating pancreatic cancer with effective therapeutic efficacy and safety in noninvasive imaging models. We developed a versatile expression vector ?VISA? (VP16-GAL4-WPRE integrated systemic amplifier) and a CCKAR (cholecystokinin type A receptor) gene-based, pancreatic-cancer-specific promoter VISA (CCKAR-VISA) composite to target transgene expression in pancreatic tumors in vivo. Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR-VISA, exhibited significant antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic orthotopic mouse models of pancreatic tumors with virtually no toxicity.
關聯:	CANCER CELL 12(1):52-65
顯示於類別:	[生物科技學系] 期刊論文

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