The role of the VEGF-C/VEGFR-3 axis in cancer progression

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/4585

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题名:	The role of the VEGF-C/VEGFR-3 axis in cancer progression
作者:	Jen-Liang Su;C-J Yen;P-S Chen;S-E Chung;C-C Hong;I-H Kuo;H-Y Chen;Mien-Chie Hung;M-L Kuo
关键词:	VEGF-C;VEGFR-3;lymphangiogenesis;metastasis
日期:	2007-02
上传时间:	2009-11-27 05:56:56 (UTC+0)
出版者:	Asia University
摘要:	Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.
關聯:	BRITISH JOURNAL OF CANCER 96(4):541-545
显示于类别:	[生物科技學系] 期刊論文

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