Survival of Cancer Cells is Maintained by EGFR Activity

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题名:	Survival of Cancer Cells is Maintained by EGFR Activity
作者:	Weihua Zhang;Rachel Tsan;Wei-Chien Huang;Qiuyu Wu;Chao-Hua Chiu;Isaiah J. Fidler;Mien-Chie Hung
日期:	2008-05
上传时间:	2009-11-27 05:56:52 (UTC+0)
出版者:	Asia University
摘要:	Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).
關聯:	CANCER CELL,13(5):385-393
显示于类别:	[生物科技學系] 期刊論文

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