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    题名: The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription
    作者: Chao-Kai Chou;Dung-Fang Lee;Hui-Lung Sun;Long-Yuan Li;Chun-Yi Lin;Wei-Chien Huang;Jung-Mao Hsu;Hsu-Ping Kuo;Hirohito Yamaguchi;Ying-Nai Wang;Mo Liu;Hsin-Yi Wu;Pao-Chi Liao;Chia-Jui Yen;Mien-Chie Hung
    关键词: AKT;MAD1;hTERT
    日期: 2009
    上传时间: 2009-11-27 05:56:51 (UTC+0)
    出版者: Asia University
    摘要: MAX dimerization protein 1 (MAD1) is a transcription suppressor that antagonizes MYC-mediated transcription activation, and the inhibition mechanism occurs mainly through the competition of target genes' promoter MYC binding sites by MAD1. The promoter binding proteins switch between MYC and MAD1 affects cell proliferation and differentiation. However, little is known about MAD1's regulation process in cancer cells. Here, we present evidence that AKT inhibits MAD1-mediated transcription repression by physical interaction with and phosphorylation of MAD1. Phosphorylation reduces the binding affinity between MAD1 and its target genes' promoter and thereby abolishes its transcription suppression function. Mutation of the phosphorylation site from serine to alanine rescues the DNA-binding ability in the presence of activated AKT. In addition, AKT inhibits MAD1-mediated target genes (hTERT and ODC) transcription repression and promotes cell cycle and cell growth. However, mutated S145A MAD1 abrogates the inhibition by AKT. Thus, our results suggest that phosphorylation of MAD1 by AKT inhibits MAD1-mediated transcription suppression and subsequently activates the transcription of MAD1 target genes.
    關聯: MOLECULAR CARCINOGENESIS 48(11):1048 - 1058
    显示于类别:[生物科技學系] 期刊論文

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