Postprandial exchange of apolipoprotein C-III between plasma lipoproteins

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题名:	Postprandial exchange of apolipoprotein C-III between plasma lipoproteins
作者:	Barr SI;Kottke BA;Mao SJT
贡献者:	Department of Biotechnology
日期:	1981-02
上传时间:	2009-11-26 01:43:40 (UTC+0)
出版者:	Asia University
摘要:	Three healthy male subjects were given a high fat meal after fasting for 12 h. Blood samples were drawn at hourly intervals over 6 h. The plasma triglyceride levels reached peak values within 3 to 6 h postprandially. Plasma cholesterol concentration, however, remained constant in the three subjects as well as in a fasting normal subject. Apolipoprotein C-III (apoC-III), a major apoprotein in triglyceride-rich lipoprotein particles and known to be exchangeable between plasma high density lipoproteins (HDL) and triglyceride-rich particles, was studied in regard to its net transfer between lipoproteins during meal absorption and postabsorptive lipolysis. ApoC-III levels in total plasma as quantitated by radioimmunoassay were stable regardless of the increase of plasma triglycerides. When triglyceride levels increased after a meal, apoC-III in the d. less than 1.063 lipoprotein fraction increased concomitantly, while apoC-III in HDL decreased. The converse was observed during lipolysis as plasma triglycerides fell. In any case, apoC-III levels in d. less than 1.063 lipoproteins were positively correlated with plasma triglycerides (r = 0.82, p less than 0.01) after the meal. The finding suggests that the apoC-III concentrations in HDL are very dynamic in vivo. ApoC-III can transfer from HDL to triglyceride-rich particles during meal absorption and can transfer from triglyceride-rich particles to HDL during postabsorptive lipolysis.
關聯:	The American Journal of Clinical Nutrition 34(2):191-8.
显示于类别:	[生物科技學系] 期刊論文

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