ASIA unversity:Item 310904400/4533
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    题名: Monoclonal antibodies to human plasma low-density lipoproteins. II. Evaluation for use in radioimmunoassay for apolipoprotein B in patients with coronary artery disease
    作者: Patton JG;Badimon JJ;and Mao SJT
    贡献者: Department of Biotechnology
    日期: 1983-11
    上传时间: 2009-11-26 01:43:36 (UTC+0)
    出版者: Asia University
    摘要: We describe the importance of the low-density lipoproteins (LDL) used in preparing radioimmunoassay standard curves and the clinical application of monoclonal antibodies to LDL. LDL isolated from five normal men produced five parallel displacement curves with conventional mouse antiserum but there was a significant difference of immunoreactivity among the LDL. None of our four monoclonal antibodies could eliminate the heterogeneous immunoreactivity of different LDL. Thus, the determination of plasma apolipoprotein (apo) B will vary depending on the selection of LDL standards, and the comparison of absolute apo B values between laboratories will be of questionable value unless they use the same LDL standard. Nonetheless, in a radioimmunoassay our monoclonal antibody, LP-22, detected a more significant (p less than 0.0001) increase of plasma apo B in patients with angiographically documented coronary artery disease than did conventional antiserum (p less than 0.001). In addition, the overlap of apo B concentrations for patients with and without disease was less when monoclonal antibody LP-22 was used. We conclude that patients with coronary artery disease have a significant increase in the form of plasma apo B that is specifically recognized by LP-22 monoclonal antibody. Perhaps monoclonal antibodies will be able to sort out the various components of apo B, delineate their possible atherogenic roles, and offer us a predictive value for diagnosing such patients.
    關聯: Clinical Chemistry 29(11):1898-903
    显示于类别:[生物科技學系] 期刊論文

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