The genetic determination of plasma apolipoprotein A-I levels measured by radioimmunoassay: a study of high-risk pedigrees

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/4522

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题名:	The genetic determination of plasma apolipoprotein A-I levels measured by radioimmunoassay: a study of high-risk pedigrees
作者:	Moll PP;Sing CF;Williams RR;Mao SJT;Kottke BA
贡献者:	Department of Biotechnology
日期:	1986-03
上传时间:	2009-11-26 01:43:33 (UTC+0)
出版者:	Asia University
摘要:	Apolipoprotein A-I (apo A-I) is the major protein component of the high-density lipoprotein (HDL) found in all primates. Using radioimmunoassay, we measured plasma apo A-I levels in 97 individuals from 23 pedigrees ascertained through cases of hypertension or early coronary artery disease (CAD). Using complex segregation analysis, we found that a genetic model with both a single locus with a major effect and polygenic loci gave the best explanation for the distribution of apo A-I levels in these pedigrees. There was no evidence for a major locus effect on HDL cholesterol in these pedigrees. This is the first study to show evidence of a major effect of a single genetic locus on the quantitative variation of plasma apo A-I in a sample of pedigrees enriched for individuals at risk for CAD.
關聯:	American Journal of Human Genetics 38(3):361-72
显示于类别:	[生物科技學系] 期刊論文

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