Intramural coronary artery disease in swine with naturally occurring hypertrophic cardiomyopathy

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/4472

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/4472

题名:	Intramural coronary artery disease in swine with naturally occurring hypertrophic cardiomyopathy
作者:	Dai KS;Chu R;Chiu YT;Lin JH;Liu SK;Hwang JP;Yang PC;Huang TY;Mao SJT
贡献者:	Department of Biotechnology
日期:	1997-12
上传时间:	2009-11-26 01:43:20 (UTC+0)
出版者:	Asia University
摘要:	Intramural coronary artery disease (ICAD) has been reported in myocardium affected with hypertrophic cardiomyopathy (HCM), but has never been studied in detail with respect to the cell type or lipid infiltration involved in the wall-thickening. The lack of heart samples may be one of the rationales to hamper the progress in investigating this disease. Recently, the discovery of naturally occurring HCM in swine has provided an excellent opportunity for the study of ICAD because of the high prevalence of ICAD in this animal. The present study provides a detailed structure feature in the thickened arterial wall of ICAD by both histologic and electron microscopic means. Morphologically, the feature of ICAD is due primarily to the neointimal thickening. Smooth muscle cells (SMC) and extracellular matrix (collagen and elastic fibers) are the major components responsible for the thickened neointima. Fragmentation of the internal elastic membrane is associated with the migration and proliferation of SMC from the media to the intima. Therefore, pigs with HCM may be a potential animal model not only for the study of the mechanism by which SMC migrate and proliferate into intima, but also for the future investigation of interventions in coronary artery occlusion.
關聯:	Journal of Submicroscopic Cytology and Pathology 29(4):511-9
显示于类别:	[生物科技學系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
		0Kb	Unknown	422	检视/开启
310904400-4472.doc		35Kb	Microsoft Word	276	检视/开启

在ASIAIR中所有的数据项都受到原著作权保护.

数据加载中.....