PDST:Protein Drug Stability Tuner a web server to improve the stability of protein drug

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题名:	PDST:Protein Drug Stability Tuner a web server to improve the stability of protein drug
作者:	Yueh-Feng Wu
贡献者:	Department of Bioinformatics
关键词:	Protein Drug;stability;Thermodynamic
日期:	2006
上传时间:	2009-11-06 14:32:06 (UTC+0)
出版者:	Asia University
摘要:	The drug stability include half life and ADME are the important factors that influence the drug efficacy. However, the resource of a number of drugs are come from proteins or peptides, which can be modified and reconstituted for every purpose. How to increase protein drug stability is the main challenge for pharmaceutical study. There are many ways to solve the problem. For example, we can enhance ionic pair, hydrophobic interaction, and hydrogen bond etc. Our tool provides prediction and modification for protein stability by calculate Temperature Index (TI) and Instability Index (II). The Temperature Index (TI) was applied to determine the Tm (Melting Temperature) directly from protein sequences. PDST(Protein Drug Stability Tuner) is a novel web online tool to provide analyzing protein drug stability and suggesting the mutation by inputting primary sequences of proteins. PDST is a freely available at http://biotuner.bio.ncue.edu.tw/pdst.htm We integrate PDB and Drug Bank, these two databases calculate the TI and II of these proteins, test and verify the result of analyzing. In according to the result, we build up a new database to provide the query of stability of protein drug.
显示于类别:	[生物資訊與醫學工程學系 ] 博碩士論文

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