The meta-analysis of the gene polymorphism related with coronary artery restenosis.

ASIA unversity > 資訊學院 > 生物資訊與醫學工程學系 > 博碩士論文 > Item 310904400/2569

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題名:	The meta-analysis of the gene polymorphism related with coronary artery restenosis.
作者:	lin kuan y?
貢獻者:	Department of Bioinformatics
關鍵詞:	artery restenosis
日期:	2007
上傳時間:	2009-11-06 14:32:05 (UTC+0)
出版者:	Asia University
摘要:	A lot of researches have shown that the cases of coronary artery restenosis are related with heredity. Mutations in the restenosis related genes maybe result in protein conformational change or decrease in protein activity. The changed fragment may be a single nucleotide or more, and its locus may be located at exon or intron. These differences are called single nucleotide polymorphism （SNP）. But these change do not exist alone, they coexist with two or more SNPs, and it may be linkage. It is reported that at least seven genes are highly relevant to restenosis, for instance, angiotensin-converting enzyme of the renin–angiotensin system (RAS) and endothelial nitric oxide synthase are two of the highly studied genes among them. In this research, patients’ data of angiotensin-converting enzyme, angiotensinogen , angiotensin II type I receptor, and endothelial nitric oxide synthase are collected through literature reviewing. Meta-analysis approach is applied to find out the linkage genes which influence the restenosis of coronary artery. The relative risk of these SNPs in restenosis of coronary artery is estimated. The results show that the D allele of ACE, aspatic acid of AGT 298, and C allele of eNOS -786 are related with restenosis of coronary. We suggest that meta-analysis of the gene polymorphism related with coronary artery restenosis must be used first before the study, and this kind of approach can be used in other area of research.
顯示於類別:	[生物資訊與醫學工程學系 ] 博碩士論文

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