Large Scale Prediction of Domain-Domain Interactions

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题名:	Large Scale Prediction of Domain-Domain Interactions
作者:	Lee Jeng-Ru
贡献者:	Department of Bioinformatics
关键词:	protein domains;domain-domain interactions prediction;protein-protein interaction prediction;domain combination pair;domain-domain interactions
日期:	2005
上传时间:	2009-11-06 14:31:41 (UTC+0)
出版者:	Asia University
摘要:	The interaction between proteins is an important feature of protein functions. Behind protein-protein interactions there are protein domains interacting with each others to perform the necessary functions. Therefore, understanding proteins interactions at the domain level gives a global view of the protein-protein interaction network. In this study, we employ the domain combination pair approach, introduced by Han et. al [Han et. al. 2004], to derive putative protein domain-domain interactions from the protein-protein interaction database DIP. Domain annotation of each protein-protein interaction record in DIP is obtained from the protein domain database, Pfam.The results of putative domain-domain interaction by Han et al. was extended to seven species (C.elegan, D.melanogaster, E.coli, H.pylori, H.sapiens, M.musculus and S.cerevisiae) and a combination of all seven species. For each case, a negative learning set (non-interacting protein sequences) is constructed in order to improve the accuracy of domain-domain interactions prediction. The predicted domain-domain interaction pairs and PIP results are available at http://210.70.80.163/kzbio2/.
显示于类别:	[生物資訊與醫學工程學系 ] 博碩士論文

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