Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

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題名:	Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury
作者:	Guan-Jhong Huang;Jeng-Shyan Deng;Shyh-Shyun Huang;Chao-Ying Lee;Wen-Chi Hou;Sheng-Yang Wang;Ping-Jyun Sung;Yueh-Hsiung Kuo
貢獻者:	保健營養生技學系
關鍵詞:	Antrodia camphorata;Eburicoic acid;Dehydroeburicoic acid;Anti-inflammation;NO;TNF-α
日期:	2013-03
上傳時間:	2013-07-11 06:02:25 (UTC+0)
摘要:	The hepatoprotective effects of eburicoic acid (TR1) and dehydroeburicoic acid (TR2) from Antrodia camphorata (AC) against carbon tetrachloride (CCl4)-induced liver damage were investigated in mice. TR1 and TR2 was administered intraperitoneally (i.p.) for 7 days prior to the administration of CCl4. Pretreatment with TR1 and TR2 prevented the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and liver lipid peroxides in CCl4-treated mice. The activities of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)], nitric oxide (NO) production, and tumour necrosis factor-alpha (TNF-α) were decreased after the treatment with TR1 and TR2 in CCl4-treated mice. Western blotting revealed that TR1 and TR2 significantly decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions and increased the expression of cytochrome P4502E1 (CYP2E1) in CCl4-treated mice. Therefore, we speculate that TR1 and TR2 protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms.
關聯:	FOOD CHEMISTRY, 141(3):3020-3027.
顯示於類別:	[食品營養與保健生技學系] 期刊論文

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