Garlic oil attenuates the cardiac apoptotosis in hamster-fed with hypercholesterol diet

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/25228

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Title:	Garlic oil attenuates the cardiac apoptotosis in hamster-fed with hypercholesterol diet
Authors:	Che, Yi-Chang;Cheng, Yi-Chang;Chan, Mu-Hsin;Chang, Mu-Hsin;Cheng-Chih, T;Tsai, Cheng-Chih;Tung-Sheng, C;Chen, Tung-Sheng;范宗宸;Fan, Ming-Jen;Chien-Chung;Lin, Chien-Chung;La, Chao-Hung;Lai, Chao-Hung;蔡輔仁;Tsai, Fuu-Jen;Lin, James A;Lin, James A;黃志揚;HUANG, CHIH-YANG
Contributors:	生物科技學系
Keywords:	Garlic oil;Hypercholesterolemia;Cardiac apoptosis;Cardiac survival
Date:	2013
Issue Date:	2013-07-11 05:56:10 (UTC+0)
Abstract:	Hypercholesterolemia is a well established risk factor for cardiac cell apoptosis. The purpose of this study is to evaluate the effects of garlic oil on cardiac apoptosis induced by a hypercholesterol diet. Twenty-four male Golden-Syrian hamsters at 3 months of age were randomly divided into three groups, control, cholesterol and garlic oil groups received a chow diet, chow diet with 2% cholesterol, and chow diet with 2% cholesterol and 1% garlic oil for 8 weeks, respectively. The TUNEL-positive apoptotic cells, and several apoptotic proteins were significantly induced in the excised left ventricle in cholesterol group, whereas significant reduction was observed in cholesterol plus garlic oil group. The IGFI receptor dependent survival pathway was inhibited in cholesterol group whereas it was obviously reversed in cholesterol plus garlic oil group. Our results suggest that administration of garlic oil shows protective effects on cardiac apoptosis in rats with high cholesterol intake.
Relation:	FOOD CHEMISTRY, V.136 N.3–4:1296–1302.
Appears in Collections:	[生物科技學系] 期刊論文

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