ASIA unversity:Item 310904400/25225
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    题名: The E?ect of Elephantopus scaber L. on Liver Regeneration after Partial Hepatectomy
    作者: Ching-Chuan;Tsai, Ching-Chuan;Wu, Jia-Ping;Wu, Jia-Ping;Lin, Yueh-Min;Lin, Yueh-Min;Yeh, Yu-Lan;Yeh, Yu-Lan;Tsung-Jung, H;Ho, Tsung-Jung;Kuo, Chia-Hua;Kuo, Chia-Hua;Tza, Bor-Show;Tzang, Bor-Show;蔡輔仁;Tsai, Fuu-Jen;蔡長海;黃志揚;HUANG, CHIH-YANG
    贡献者: 生物科技學系
    日期: 2013
    上传时间: 2013-07-11 05:56:04 (UTC+0)
    摘要: Liver regeneration after partial hepatectomy (PHx) is a physiological response for maintaining homeostasis. The aim of this study is to investigate effects of Elephantopus scaber L.- (ESL-) induced liver regeneration on growth factors (HGF and IGF-1), cell cycle regulation, and apoptosis suppressed. In this study, we fed five Chinese medicinal herbs (1 g/kg/day), Codonopsis pilosula (CP, Dangshen), Salvia miltiorrhiza Bunge (SMB, Danshen,), Bupleurum kasi (BK, Chaihu), Elephantopus scaber L. (ESL, Teng-Khia-U), and Silymarin (Sm, 25 mg/kg) for 7 days to male Spraue-Dawley rats. Then surgical 2/3 PHx was conducted and liver regeneration mechanisms were estimated on the following 24 hrs and 72 hrs. The activities of growth factors (HGF and IGF-I) and cell cycle proteins were measured by Western blot and RT-PCR. Histological analysis and apoptosis were detected by H&E stain and TUNEL. The results showed that extraction of Elephantopus scaber L. (ESL) and Silymarin (Sm, positive control) were increased protein expression levels of HGF and IGF-1 which leads into cell cycle. These results suggest that the ESL plays a crucial role in cell cycle-induced liver regeneration and apoptosis. These results suggested that the ESL plays a crucial role in cell cycle-induced liver regeneration and suppressed hepatocytes apoptosis.
    關聯: Evidence-based Complementary and Alternative Medicine; 2013:369180.
    显示于类别:[生物科技學系] 期刊論文

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