Suppression of TLR-4-Related Inflammatory Pathway and Anti-Fibrosis Effects of Probiotic-Fermented Purple Sweet Potato Yogurt in Hearts of Spontaneously Hypertensive Rats

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题名:	Suppression of TLR-4-Related Inflammatory Pathway and Anti-Fibrosis Effects of Probiotic-Fermented Purple Sweet Potato Yogurt in Hearts of Spontaneously Hypertensive Rats
作者:	Lin, Pei-Pei;Lin, Pei-Pei;Hsi, You-Miin;Hsieh, You-Miin;Kuo, Wei-Wen;Kuo, Wei-Wen;Lin, Yueh-Min;Lin, Yueh-Min;Yeh, Yu-Lan;Yeh, Yu-Lan;Chien-Chung;Lin, Chien-Chung;Tsai, Fuu-Jen;Tsai, Fuu-Jen;蔡長海;Cheng-Chih, T;Tsai, Cheng-Chih;黃志揚;HUANG, CHIH-YANG
贡献者:	生物科技學系
日期:	2013
上传时间:	2013-07-11 05:55:59 (UTC+0)
摘要:	Inflammation plays an important role in triggering fibrosis of cardiovascular disease and hypertension. Gamma-aminobutyric acid (GABA) has hypotensive effect; GABA concentration could be enhanced in milk fermented with lactic acid bacteria (LAB). This study evaluated the effect of probiotic-fermented purple sweet potato yogurt (PSPY) on the toll-like receptor 4 (TLR-4)-related inflammatory components, and on fibrosis in the heart of spontaneously hypertensive rat (SHR). TLR4- related pathway and fibrosis-associated proteins TGFβ and FGF2 were significantly increased in SHR hearts, but were highly suppressed in 10% PSPY-fed rats. Microscopic examination with Masson trichrome staining of left ventricle further demonstrated that 10% and 100% PSPY both significantly reduced interstitial fibrosis in SHR hearts. These findings indicated that oral administration of 10% probiotic-fermented PSPY was strong enough to lower cardiac fibrosis in SHR rats through the suppression of TLR-4-related inflammatory pathway. Therefore, PSPY may be included in diets to help prevent cardiac fibrosis in patients with hypertension.
關聯:	CHINESE JOURNAL OF PHYSIOLOGY
显示于类别:	[生物科技學系] 期刊論文

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