Herbal Supplement Attenuation of Cardiac Fibrosis in Rats with CCl4-Induced Liver Cirrhosis

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題名:	Herbal Supplement Attenuation of Cardiac Fibrosis in Rats with CCl4-Induced Liver Cirrhosis
作者:	Hsiao-Chuan;Chang, Hsiao-Chuan;Chi, Yung-Wei;Chiu, Yung-Wei;Lin, Yueh-Min;Lin, Yueh-Min;Che, Ray-Jade;Chen, Ray-Jade;James, A.Lin;James, A.Lin;蔡輔仁;Tsai, Fuu-Jen;蔡長海;郭昱君;Liu, Jer-Yuh;Liu, Jer-Yuh;黃志揚;HUANG, CHIH-YANG
貢獻者:	生物科技學系
日期:	2013
上傳時間:	2013-07-11 05:55:57 (UTC+0)
摘要:	Previously we found carbon tetrachloride (CCl₄) induced cirrhosis associated cardiac hypertrophy and apoptosis. The purpose of this study is to determine whether further CCl₄ treatment would induce cardiac cell fibrosis. The cardiac tissues were analyzed by H&E. histological staining, Trichrome Masson staining and Western blotting. The results showed that the CCl₄-treated-only group exhibits more trichrome staining, meaning that more fibrosis is present. Moreover, CCl₄ could further induce cardiac-fibrosis via TGF-β-p-Smad2/3-CTGF pathway. However, our data showed that the CCl₄- indcued cardiac abnormalities were attenuated by Ocimum gratissimum extract (OGE) and silymarin co- treatments. In conclusion, our results indicated that the OGE and silymarin may be a potential traditional herb for the protection of cardiac tissues from the CCl4 induced cirrhosis associated cardiac fibrosis through modulating the TGF-β signaling pathway.
關聯:	CHINESE JOURNAL OF PHYSIOLOGY
顯示於類別:	[生物科技學系] 期刊論文

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