PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/25192

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Title:	PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation
Authors:	梁雅珍;Liang, Ya-Chen;許巧雨;Hsu, Chiao-Yu;姚雅莉;Yao, Ya-Li;楊文明;Yang, Wen-Ming
Contributors:	生物科技學系
Date:	2013-02
Issue Date:	2013-07-11 05:55:06 (UTC+0)
Abstract:	Poly(ADP-ribose) polymerase-2 (PARP-2) catalyzes poly(ADP-ribosyl)ation (PARylation) and regulates numerous nuclear processes, including transcription. Depletion of PARP-2 alters the activity of transcription factors and global gene expression. However, the molecular action of how PARP-2 controls the transcription of target promoters remains unclear. Here we report that PARP-2 possesses transcriptional repression activity independently of its enzymatic activity. PARP-2 interacts and recruits histone deacetylases HDAC5 and HDAC7, and histone methyltransferase G9a to the promoters of cell cycle-related genes, generating repressive chromatin signatures. Our findings propose a novel mechanism of PARP-2 in transcriptional regulation involving specific protein-protein interactions and highlight the importance of PARP-2 in the regulation of cell cycle progression. Copyright © 2012 Elsevier Inc. All rights reserved.
Relation:	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS;431(1):58-64.
Appears in Collections:	[生物科技學系] 期刊論文

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